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Cat. No.	Product Name	Target	Signaling Pathways
T15180	Duocarmycin A	Caspase	Apoptosis; Proteases/Proteasome
	Duocarmycin A, an antitumor antibiotic, is a DNA alkylator and efficiently alkylates adenine N3 at the 3′ end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results in HLC-2 cells typically apoptotic changes.
T11120	Duocarmycin TM	DNA Alkylation; Antibiotic	DNA Damage/DNA Repair; Microbiology/Virology
	Duocarmycin TM 是一种有抗肿瘤活性的抗生素，也是一种 DNA 烷化剂。
T73948	Duocarmycin DM
	Duocarmycin DM，一种DNA小沟烷基化剂（DNA minor-groove alkylator），作为抗体活性分子结合物（ADCs）的毒素，因其独特结构显示出抗癌活性。
T63523	Duocarmycin analog-2
	Duocarmycin analog-2 是有效的 DNA 烷基化剂，表现出抗肿瘤作用，能够用于免疫偶联物的合成。
T11117	Duocarmycin MB	Others	Others
	Duocarmycin MB can be used against multi-drug resistant cell lines. Duocarmycin MB is an antibody drug conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove.
T11116	Duocarmycin MA	Others	Others
	Duocarmycin MA can be used against multi-drug resistant cell lines.Duocarmycin MA is an antibody drug conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove.
T11119	Duocarmycin DM free base Duocarmycin	Others	Others
	Duocarmycin is a DNA minor groove binding alkylating agent and explored as drug–antibody conjugates (ADCs) . Duocarmycin is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity.
T12813L	Seco-Duocarmycin SA	DNA Alkylation	DNA Damage/DNA Repair
	Seco-Duocarmycin SA is a highly potent DNA alkylator used as an ADC cytotoxin.
T12813	(S)-Seco-Duocarmycin SA	Others	Others
	(S)-Seco-Duocarmycin SA is a DNA alkylator, acts as a ADC cytotoxin for antibody-drug conjugates.
T70462	Pibrozelesin
	Pibrozelesin is a water-soluble derivative of duocarmycin B2 that alkylates DNA by binding to adenine-thymine (A-T)-rich sequences in the minor groove of DNA, thereby inhibiting DNA replication and inducing apoptosis.
T17982	Fmoc-Val-Cit-PAB-Duocarmycin TM	Others	Others
	Fmoc-Val-Cit-PAB-Duocarmycin TM is a drug-linker conjugate designed for antibody-drug conjugation (ADC), utilizing the antitumor antibiotic Duocarmycin TM. It is connected through the linker Fmoc-Val-Cit-PAB.
T18324	MC-Val-Cit-PAB-duocarmycin chloride MC-Val-Cit-PAB-duocarmycin	Others	Others
	MC-Val-Cit-PAB-duocarmycin is an antibody-drug conjugate (ADC) linker that combines duocarmycin, a potent DNA minor groove-binding alkylating agent, with an antitumor drug through the MC-Val-Cit-PAB linker, exhibiting significant antitumor activity.
T38611	Seco-DUBA
	Seco-DUBA, a duocarmycin (DUBA) prodrug, possess two hydroxyl groups suitable for antibody coupling through a linker. This compound, serving as a precursor, enables the synthesis of antibody-drug conjugates (ADCs).
T11115	Duocarmycin GA	Others	Others
	Duocarmycin GA, an antibody drug conjugate (ADC) toxin and a DNA alkylating agent, effectively targets and binds in the minor groove of DNA. It is particularly potent against multi-drug resistant cell lines, offering a strategic approach in combating resistance.

化合物

Duocarmycin A

Cat.No: T15180

Target: Caspase

Duocarmycin TM

Cat.No: T11120

Target: DNA Alkylation, Antibiotic

Duocarmycin DM

Cat.No: T73948

Duocarmycin analog-2

Cat.No: T63523

Duocarmycin MB

Cat.No: T11117

Target: Others

Duocarmycin MA

Cat.No: T11116

Target: Others

Duocarmycin DM free base

Cat.No: T11119

Synonym: Duocarmycin

Target: Others

Seco-Duocarmycin SA

Cat.No: T12813L

Target: DNA Alkylation

(S)-Seco-Duocarmycin SA

Cat.No: T12813

Target: Others

Cat.No: T70462

Fmoc-Val-Cit-PAB-Duocarmycin TM

Cat.No: T17982

Target: Others

MC-Val-Cit-PAB-duocarmycin chloride

Cat.No: T18324

Synonym: MC-Val-Cit-PAB-duocarmycin

Target: Others

Cat.No: T38611

Duocarmycin GA

Cat.No: T11115

Target: Others

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